Sunday, May 4, 2008

Sunday May 4, 2008

Q: What is the ratio of alpha and beta blockade in Labetalol?



A: As an anti-hypertensive, Labetalol has both alpha-blockade and beta-blockade activity. The ratio of alpha to beta blockade activity is


1:3 when used Orally
1:7 when used intravenously




References:

1. I.V. LABETALOL AND CORONARY ARTERY SURGERY, MOREL et al. Br. J. Anaesth..1984; 56: 664-665

2. Comparative study of esmolol and labetalol to attenuate haemodynamic responses after electroconvulsive therapy - Kathmandu University Medical Journal (2007), Vol. 5, No. 3, Issue 19, 318-323, pdf file